COMET

Search for new determinants of type 2 diabetes in severe obesity – Collection of human metabolic tissues.

Collaborative project between the University of Montpellier, Montpellier University Hospital, SATT AXLR, and Servier.

The strong need for innovation in the field of metabolic diseases and type 2 diabetes requires access to human samples from patients, which will be a source of discovery for future drug targets or new biomarkers.

The COMET biobank is a clinical research protocol conducted under the auspices of Montpellier University Hospital, which collects muscle, liver, subcutaneous and visceral adipose tissue, serum and plasma, DNA, and RNA from morbidly obese patients with different metabolic profiles. Extensive clinical and biological data are collected for each patient included in the study.

The samples have already led to the discovery of potential therapeutic targets (Laget et al., Diabetes & Metabolism, 2022) and biomarkers (Rivère et al., Diabetes & Metabolism, 2022) for improving the management of type 2 diabetes and its comorbidities.