COMET

Search for new risk factors for type 2 diabetes in severe obesity – Collection of human metabolic tissues.

A collaborative project between the University of Montpellier, Montpellier University Hospital, SATT AXLR, and Servier.

The urgent need for innovation in the field of metabolic diseases and type 2 diabetes requires access to human samples from patients, which will serve as a source of discovery for future drug targets or new biomarkers.

The COMET Biobank is a clinical research protocol, led by the Montpellier University Hospital, that collects muscle, liver, subcutaneous and visceral adipose tissue, serum and plasma, DNA, and RNA from morbidly obese patients with different metabolic profiles. Extensive clinical and biological data are collected for each patient enrolled in the study.

The samples have already led to the identification of potential therapeutic targets (Laget et al., Diabetes & Metabolism, 2022) and biomarkers (Rivère et al., Diabetes & Metabolism, 2022) to improve the management of type 2 diabetes and its comorbidities.