COMET

Search for new determinants of type 2 diabetes in severe obesity - Human metabolic tissue collection.

Collaborative project between Université de Montpellier, CHU de Montpellier, SATT AXLR, Servier.

The strong need for innovation in the field of metabolic diseases and type 2 diabetes requires access to human samples from patients, which will be a source of discovery for future drug targets or new biomarkers.

The COMET biobank is a clinical research protocol, conducted under the auspices of Montpellier University Hospital, which brings together muscle, liver, subcutaneous and visceral adipose tissue, serum and plasma, DNA and RNA from morbidly obese patients with different metabolic profiles. Numerous clinical and biological data are collected for each patient included.

The samples have already led to the discovery of potential therapeutic targets (Laget et al., Diabetes & Metabolism, 2022) or biomarkers (Rivère et al., Diabetes & Metabolism, 2022) to improve the management of type 2 diabetes and its co-morbidities.